منابع مشابه
The Bowel Microbiota and Inflammatory Bowel Diseases
The human bowel contains a large and biodiverse bacterial community known as the microbiota or microbiome. It seems likely that the microbiota, fractions of the microbiota, or specific species comprising the microbiota provide the antigenic fuel that drives the chronic immune inflammation of the bowel mucosa that is characteristic of Crohn's disease and ulcerative colitis. At least twenty years...
متن کاملThe microbial basis of inflammatory bowel diseases.
Inflammatory bowel diseases (IBD) are chronic, progressive diseases characterized by aberrant immune responses to environmental and gut microbial triggers in genetically susceptible hosts. Clinical, genetic, and experimental data support the role of gut microbes in causing and sustaining these diseases. Our understanding of IBD has changed dramatically as the result of advances in cultivation-i...
متن کاملThe molecular biology of inflammatory bowel diseases.
IBDs (inflammatory bowel diseases) are a group of diseases affecting the gastrointestinal tract. The diseases are multifactorial and cover genetic aspects: susceptibility genes, innate and adaptive responses to inflammation, and structure and efficacy of the mucosal protective barrier. Animal models of IBD have been developed to gain further knowledge of the disease mechanisms. These topics for...
متن کاملThe microbial basis of inflammatory bowel diseases
The inflammatory bowel diseases (IBD) are a group of chronic diseases that result from a confluence of genetic and environmental triggers. IBD have two main clinical phenotypes, ulcerative colitis (UC) and Crohn’s disease (CD). UC is characterized by mucosal inflammation that is limited to the colon, beginning in the rectum and extending proximally in a continuous and circumferential fashion. C...
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ژورنال
عنوان ژورنال: The Boston Medical and Surgical Journal
سال: 1901
ISSN: 0096-6762,1533-4406
DOI: 10.1056/nejm190109051451002